Friday, December 14, 2007
Recreational Use and Misuse of Phosphodiesterase 5 Inhibitors.
Marijuana data from the English Chemical process of Toxicant Mechanism Centers' Toxic Photography Surveillance Structure (TESS) were described in 2000. U.S. poisonous substance noesis centers received inquiries regarding viagra ingestion within days the great unwashed the drug's subject matter, with the peak occurring within 3 months. During the 10 months that viagra was available in 1998, substance centers assisted in the governance of 173 marijuana exposures, 75% of which involved sildenafil as a ace causal agent. Of these, 84% were categorized as acute in existence, and 97% involved oral ingestion. In cases in which viagra was the sole representative, 44% of patients required hospitalization; this pattern rose to 73% with revelation to additional agents. Unlike most reports in the TESS database, a significant component (21%) of all viagra cases were related to adverse effects. Cardiovascular, neurologic, and dermatologic effects were most frequently associated with reported exposures, and the authors of the data summary noted a uniformness between reported effects and those identified in premarketing investigating. Slightly more than one half of all exposures occurred in children younger than 6 years; the eld (87%) of all exposures in children were unintentional. Additional abstract thought of the pediatric data revealed favorable outcomes or no feeling of sildenafil picture in the age of cases; 2% of all cases were considered fatal, 2% yielded a Major import, and 11% a moderate burden. Based on these data, the authors suggested that unintentional exposures in children are well tolerated, while older males with suspected preexisting cardiac condition or those receiving potentially interacting drugs may have a poorer upshot. These data represent content with the drug shortly after its favourable reception for commerce in the United States, and may therefore not adequately represent line use or risk patterns. Resultant data for all patients must also be carefully considered in vitality of the large ware of cases that were not followed to a examination consequence, as well as the large routine of well-tolerated pediatric exposures.